FPP — Candida albicans

Summary

C2_04580W_A (FPP, also known as ERG20) encodes a protein with geranyltranstransferase, dimethylallyltransferase and farnesyltranstransferase activities, belonging to the polyprenyl synthetase family. This gene is associated with the production of farnesyl diphosphate, geranylgeranyl diphosphate, ergosterol, and other sterols and isoprenoids. FPP is linked to biofilm formation, filamentous growth, invasive growth, sporulation, and viability. It is also associated with responses to pH, nutrient availability, and carbon source utilization, as well as to cell cycle progression, mitochondrial morphology and function, and endoplasmic reticulum morphology. The gene product localizes to the cytoplasm, cytosol, endoplasmic reticulum, nucleus, and the fungal biofilm matrix. Studies of related genes in other species link the family to colony sectoring and auxotrophy.