GWT1 — Candida albicans

Summary

C2_05730C_A (GWT1, CaGWT1) on Candida albicans chromosome 2 encodes a glucosaminyl-phosphatidylinositol O-acyltransferase of the PIGW/GWT1 family. The gene is associated with GPI anchor metabolism, GPI anchor anabolism, protein maturation, cell wall assembly, and protein localization to the plasma membrane. It is linked to hyphal growth, germ tube formation, tube formation, and biofilm formation. Associations with abnormal flocculation, budding, cytokinesis, cell cycle progression, and decreased vegetative growth, mating efficiency, and survival in stationary phase have been observed. The gene is also linked to increased chitin deposition, telomere length, and killer toxin resistance, as well as decreased cold sensitivity and alkaline pH resistance. The encoded protein localizes to the endoplasmic reticulum membrane. Related genes in other species link the family to abnormal cell size, cell wall morphology, and nutrient uptake.