TPK2 — Candida albicans

Summary

C2_07210C_A (TPK2, CaTPK2) on Candida albicans chromosome 2 encodes a protein with AGC-kinase and protein kinase domains, exhibiting novel protein kinase C, ribosomal protein S6 kinase, cAMP-dependent protein kinase, and protein serine/threonine kinase activities, along with lipid binding and signaling adaptor functions. This gene is associated with negative regulation of cytoplasmic mRNA processing body assembly, fungal-type cell wall 1,3-beta-glucan metabolism, G1/G0 transition, cell-abiotic substrate adhesion, downregulation of filamentous growth in response to chemical stimuli, regulation of osmotic stress response, and positive regulation of RNA polymerase III transcription. It localizes to the cAMP-dependent protein kinase complex, actomyosin contractile ring, P body, stress granule, division septum, nucleoplasm, and vacuolar membrane. Phenotypic associations include abnormal biofilm formation, increased acquired thermotolerance, increased adhesion, decreased lifespan, increased polyploidy rate, and abnormal spore germination. Studies of related genes in other species link the family to protein kinase activities and pathogenicity outcomes.