CSH1 — Candida albicans

Summary

C2_09150W_A (CSH1, also known as MIT1) in Candida albicans encodes a mannosyltransferase with inositol phosphorylceramide mannosyltransferase activity (EC 2.4.1.370), placing it within the glycosyltransferase domain family. This gene is associated with M(IP)2C metabolism, MIPC biosynthetic process, and inositolphosphoceramide metabolism, as well as biofilm formation, pseudohyphal growth, invasive growth, quorum sensing, immune evasion, cell adhesion, membrane organization, oxidative phosphorylation, and vitamin and cysteine anabolism. The encoded protein localizes to the Golgi complex, cis- and trans-Golgi network membranes, and ER membrane. Phenotypic associations include decreased autophagy and pexophagy rates, absent flocculation, decreased cell cycle progression, delayed vacuolar transport and endocytosis, abnormal filamentous and pseudohyphal growth, increased fermentative growth, and increased freeze-thaw resistance. Related genes in other species link the family to acid sensitivity.