BD — Candida albicans

Summary

C2_10210C_A (BD, RAS1) on Candida albicans chromosome 2 encodes a small GTPase of the Ras-type family with GTPase activity, GDP, GTP, CTP and UTP binding, and protein serine/threonine kinase activator activity. It is associated with farnesol anabolism and response, cAMP/PKA signaling, filament development, morphogenesis regulation, thigmotropism, chemotropism, cell-cell signaling, hypoxia response, proline and pyruvate metabolism, and phenotypic switching upregulation. Localisation includes the plasma membrane, cytoplasm, nucleus, division septum, and mating projection actin fusion focus. Phenotypic associations link it to decreased vacuolar transport, absent bipolar budding, increased mating-type switching, decreased G0 entry, absent osmotic and oxidative stress resistance, delayed nuclear export, abnormal pheromone production, increased protein transport, and decreased flocculation. Related genes in other species are linked to virulence and oxidative stress response.