CREA — Candida albicans

Summary

C2_10540W_A (CaCREA) encodes a transcription factor of the CreA/MIG family, with DNA-binding activity. It is associated with negative regulation of glucose-responsive transcription, carbon utilization control, germ tube formation, quorum sensing, cell adhesion, and innate immune responses. The gene product localizes to both cytoplasm and nucleus. Phenotypic associations link CaCREA to abnormal pseudohyphal growth, absent adhesion, decreased fermentative growth, altered cell cycle progression, increased sporulation, and reduced UV and ionizing radiation resistance. It has also been connected to disseminated candidiasis in human and mouse models. Studies of related genes in other species associate the family with sugar content, germination rate, acid sensitivity, and oxidative stress response.