ESA1 — Candida albicans

Summary

ESA1 (C3_00490W_A) in Candida albicans encodes a MYST-family histone acetyltransferase with histone H4K16, H4K5, H4K12, and H3K4 acetyltransferase activities, as well as peptide butyryltransferase, 2-hydroxyisobutyryltransferase, and crotonyltransferase activities. The protein contains MYST_HAT, Tudor-knot, Zf-MYST, chromo, and acyl-CoA acyltransferase domains. ESA1 is associated with chromatin binding, transcriptional co-regulation, DNA repair-dependent chromatin remodeling, transcription elongation, and regulation of phenotypic switching. It is linked to cell fate determination, hyphal growth, filamentous growth, morphogenesis, negative regulation of filamentous growth, positive regulation of triglyceride biosynthesis, and upregulation of heterochromatin formation and macroautophagy. The gene is also associated with cell cycle modulation, DNA damage response, stress response, and regulation of secondary metabolite biosynthesis. ESA1 localizes to the nucleus, chromatin, centric heterochromatin, the Piccolo histone acetyltransferase complex, and sites of double-strand breaks.