FLO9 — Candida albicans

Summary

C3_00580W_A (FLO9) on Candida albicans chromosome 3 encodes a protein containing a hyphal-regulated cell wall N-terminal domain and agglutinin-like ALS repeats. The gene is associated with flocculation, cell-substrate adhesion, fungal-type cell wall organization, morphogenesis, fermentation, telomere localization, and TNF production. Its product localizes to the side of the membrane, the fungal-type cell wall, the cell surface, and the extracellular space. Studies of related genes in other species link this family to reduced virulence and unaffected pathogenicity, though these associations are not yet established for FLO9 itself.