MNT1 — Candida albicans

Summary

C3_01810C_A (MNT1, CaMNT1) on Candida albicans chromosome 3 encodes a mannosylphosphate transferase with alpha-1,2-mannosyltransferase activity, belonging to the Glyco_trans_15 and nucleotide-diphossugar_trans families. The gene is associated with protein O-linked and N-linked glycosylation, mannan and cell wall mannoprotein anabolism, N-glycan processing, and cell wall biogenesis and organization. It is associated with biofilm formation, cell-cell and cell-matrix adhesion, cell adhesion involved in multi-species biofilm formation, asexual sporulation, secretion, and interaction with host, including mitigation of host defenses and immune response. The product localizes to the Golgi membrane and complex, ER membrane, plasmalemma, cytoplasm, cytosol, and nucleus, and is also found extracellularly. Related genes in other species encode alpha-1,2-mannosyltransferases.