GPT1 — Candida albicans

Summary

Candida albicans gene GPT1 (also known as KRE5) on chromosome 3 encodes a protein with UDP-glucose:glycoprotein glucosyltransferase (UGGT) activity, which also binds D-mannose, misfolded proteins, and calcium ions. The gene is associated with beta-glucan, 1,6-beta-glucan, and glycoprotein biosynthesis, N-glycan processing, cell wall assembly and organization, filamentous growth in response to neutral pH, starvation, and biotic stimuli, cellular responses to starvation and xenobiotic stimuli, cell aggregation, digestion, GABA transport, M phase, protein breakdown, and ER localization. Phenotypic associations include abnormal cell cycle progression, colony size, cell size and shape, budding pattern, nuclear and mitochondrial morphology, increased autophagy and killer toxin resistance, decreased fermentative and respiratory growth, and altered responses to hyperosmotic stress and enzymatic treatment. Studies of related genes in other species link the family to abnormal cellular morphology and nucleolar size.