ABCA — Candida albicans

Summary

C3_04070C_A (ABCA, also known as CDR11) in Candida albicans encodes an ABC-type xenobiotic transporter belonging to the PDR/CDR family, with ATP-binding and transmembrane domains. The protein exhibits azole, fluconazole, and xenobiotic transmembrane transporter activity, as well as estradiol and corticosterone binding, and is associated with phosphatidylethanolamine, phosphatidylcholine, and phosphatidylserine floppase activity and aminophospholipid flippase activity. It is associated with azole and fluconazole transport, response to antibiotics, xenobiotic stimulus, and progesterone, as well as sterol homeostasis, phospholipid translocation, and mRNA transcription. Localized to the plasma membrane, membrane, and extracellular vesicles, the gene is linked to abnormal small molecule transport, increased fermentative growth, decreased cell death, altered pseudohyphal growth, and abnormal replicative and chronological lifespan. Related genes in other species connect the family to multidrug resistance and stress responses.