BD — Candida albicans

Summary

C3_05180W_A (BD, RHB1) on Candida albicans chromosome 3 encodes a small GTPase of the Ras-type family with GDP and GTP binding, GTPase activity, G protein activity, and protein activator activity. It is associated with farnesol anabolism and response, filament development, thigmotropism, chemotropism, cell-cell signaling, response to hypoxia, regulation of morphogenesis, proline and pyruvate metabolism, OXPHOS, secretion, and cytokine production. The protein localizes to the plasma membrane, endomembrane system, cytosol, and nucleus. Phenotypic associations include decreased vacuolar transport, absent bipolar budding, decreased redox state, altered mating type switching, decreased entry into G0, absent osmotic and oxidative stress resistance, decreased flocculation, and delayed nuclear export. Related genes in other species link the family to protein content and oxidative stress response.