KRE6 — Candida albicans

Summary

C3_05810C_A (KRE6, also known as SKN1) in Candida albicans encodes a GH16 family protein with a ConA-like domain superfamily and glucosidase activity, localized to the Golgi membrane, ER membrane, and plasma membrane. The gene is associated with cell wall organization or biogenesis, including 1,6-beta-glucan and chitin anabolism, as well as cell wall assembly and biogenesis. It is linked to biofilm formation, hyphal growth, morphogenesis, ergosterol anabolism, regulation of cytoskeleton organization, cell death, and cell growth. Phenotypic associations include abnormal cell cycle progression, decreased cytokinesis, increased thermotolerance, abnormal filamentous growth, and increased polyploidy. Related genes in other species are linked to beta-glucan synthesis and cell wall integrity. The gene is also connected to disseminated candidiasis in humans and mouse models.