CHO1 — Candida albicans

Summary

C3_06570C_A (CHO1, also known as OPI3) in Candida albicans encodes a phospholipid methyltransferase (EC 2.1.1.71) belonging to the PEMT/MFAP family. This enzyme is associated with phosphatidylcholine, phosphatidylserine, and phosphatidylethanolamine anabolism, as well as ergosterol and ATP anabolism, the Kennedy pathway, and phospholipid metabolism. The gene is linked to cell wall biogenesis, hyphal growth, morphogenesis, plasma membrane and ER organization, secretion, quorum sensing, and cell development. It localizes to the ER and mitochondrial membranes. Associations include copper sensitivity, oxidative stress response, and altered apoptosis, autophagy, cell cycle progression, vegetative growth, and spore germination. Studies of related genes in other species link the family to nitrogen source utilization and respiratory growth.