CAN1 — Candida albicans

Summary

CaCAN1 (C3_06710W_A) encodes a member of the SLC12A family and has been annotated with potassium:chloride symporter activity. The gene is associated with chloride and potassium ion homeostasis, vacuolar membrane transport, cell volume homeostasis, and chloride transmembrane transport. It is linked to vacuolar membrane localization and has been connected to numerous phenotypes in Candida albicans, including absent biofilm formation, increased cell death, decreased osmotic stress resistance, increased hyperosmotic stress resistance, absent pseudohyphal and invasive growth, increased filamentous growth, decreased telomere length, and increased innate thermotolerance. Additional associations include nitrogen catabolite repression, response to heat and stress, plasma membrane organization, and double-strand break repair. Studies of related genes in other species link the family to haploinsufficiency phenotypes.