HH3 — Candida albicans

Summary

C3_07090W_A (HH3, also known as HHT1) encodes a protein with a histone H3/CENP-A domain and histone-fold domain, and is a structural constituent of chromatin that binds nucleosomal DNA and possesses protein heterodimerization activity. In Candida albicans, this gene is associated with kinetochore assembly, centromere localization and separation, mitotic metaphase chromosome alignment, anaphase, and cell cycle regulation. It is linked to mating type switching, gene conversion, chromatin silencing, and fungal-type cell wall assembly. Phenotypic associations include altered cell cycle progression through G2/M and G1/S transitions, premature meiosis and sporulation, increased gamma ray resistance, decreased hypoosmotic stress resistance, and abnormal mitophagy and vacuolar morphology. The protein localizes to the nucleosome, kinetochore, and nucleus.