FRP1 — Candida albicans

Summary

C4_00110C_A (FRP1) in Candida albicans chromosome 4 encodes a ferric/cupric reductase with domains including Fe_red_NAD-bd_6, FAD-bd_8, and a ferric reductase transmembrane domain. The enzyme has NADH:Fe3+ oxidoreductase activity (EC 1.16.1.9), iron chelate reductase activity, and haem transporter activity. FRP1 is associated with iron and copper import into the cell, heme import, cellular response to iron ion starvation, and iron homeostasis. It is also linked to filamentous growth, hyphal growth, morphogenesis, cell death, and ergosterol anabolism. The protein localizes to the plasma membrane and ER membrane. Studies of related genes in other species link the family to reduced virulence and vascular wilt, though these associations are not established for C. albicans FRP1 itself.