CAS5 — Candida albicans

Summary

C4_01190W_A (CAS5) on Candida albicans chromosome 4 encodes a transcription factor with DNA-binding and transcriptional co-regulator activity. The gene is associated with cellular response to cold, sporocarp development in asexual reproduction, positive regulation of conidium formation, autolysis, and regulation of ergosterol and sterigmatocystin biosynthetic processes. CAS5 is linked to development of the symbiont in the host, positive regulation of cell-substrate adhesion, upregulation of cell adhesion in single-species biofilm formation, response to starvation, glucan anabolism, cell wall biogenesis, iron transport, and conidia formation. The encoded product localizes to the nucleus, cytoplasm, chromatin, and transcription regulator complex. Related genes in other species link the family to invasive pulmonary aspergillosis.