AIM2 — Candida albicans

Summary

CaAIM2 (C4_01840C_A) encodes a protein containing an AB hydrolase domain and a dienelactone hydrolase domain, with hydrolase activity annotated on this gene. In Candida albicans, CaAIM2 is associated with antimicrobial peptide secretion, type I IFN production, IL-17 production, IL-1 production, inflammatory response, immune response, cell death, autophagy, memory, and secretion. The protein localizes to both the cytosol and nucleus. Phenotypic associations include decreased vegetative growth rate, decreased heat sensitivity, abnormal vacuolar morphology, altered competitive fitness, auxotrophy, and changes in carbon source utilization, stress resistance, and chemical resistance. Studies of related genes in other species link the AIM2 family to decreased filamentous growth and absent invasive growth, though these associations are not established for CaAIM2 itself.