SOD1 — Candida albicans

Summary

C4_02320C_A (SOD1) on Candida albicans chromosome 4 encodes a copper- and zinc-binding superoxide dismutase (EC 1.15.1.1) with oxidoreductase activity acting on sulphur-group donors and oxygen as acceptor. The gene is associated with superoxide metabolism, removal of O2-, oxidative stress response, and inhibition of oxidative metabolism, as well as with copper ion transport, polyphosphate and cAMP anabolism, glutathione anabolism, nitrogen and sulfur utilization, and response to zinc. It has been linked to germ tube formation, protein stabilization, structural organization, and innate immunity. Localization evidence places the product in the cytoplasm, cytosol, nucleus, mitochondrial envelope lumen, and extracellular. Associations with candidiasis and with traits such as protein content, oxidative stress resistance, desiccation resistance, freeze-thaw resistance, and altered fermentative growth have been reported.