CDR3 — Candida albicans

Summary

CDR3 (C4_03620C_A) on chromosome 4 of Candida albicans encodes a member of the ABC2 transmembrane family. The protein exhibits multiple transport activities, including azole, fluconazole, and xenobiotic transmembrane transporter activity, as well as flippase and floppase activities for phospholipids such as phosphatidylcholine, phosphatidylethanolamine, and phosphatidylserine. It also binds estradiol and corticosterone. CDR3 is associated with response to antibiotics, xenobiotics, and peptides, azole and fluconazole transport, phospholipid translocation, xenobiotic detoxification, ergosterol anabolism, and cellular cation homeostasis. It is linked to immune response, cytokine production, innate immunity, memory, and type IV hypersensitivity. The protein localizes to the plasma membrane, membrane, vacuolar lumen, and extracellular vesicles. Studies of related genes in other species link the family to virulence and pathogenicity.