SAP10 — Candida albicans

Summary

C4_04470W_A (SAP10) in Candida albicans chromosome 4 encodes an aspartic endopeptidase (EC 3.4.23.24) with metal-binding capability, belonging to the SAP-like aspartic peptidase A1 family. The gene is associated with proteolysis, protein breakdown, and protein processing, as well as with biofilm formation, invasive growth, morphogenesis, and fungal-type cell wall organization. It is linked to host interaction processes including adhesion of symbiont to host, transepithelial migration, perturbation of host immune response, innate immunity, NK cell activation, phagocytosis, fibrinolysis, and blood clotting. The encoded product localizes to the fungal-type cell wall, plasmalemma, side of membrane, and extracellular vesicles. Studies of related genes in other species link this gene family to virulence modulation, including reduced virulence and hypervirulence, and to candidiasis.