GAT1 — Candida albicans

Summary

C4_05880W_A (GAT1) on Candida albicans chromosome 4 encodes a GATA-family transcription factor with DNA-binding transcription activator and repressor activity specific to RNA polymerase II, containing zinc-binding GATA and AreA_GATA domains. The gene is associated with nitrogen catabolite repression, regulation of nitrogen utilization, nitrate assimilation, urea metabolism, and arginine breakdown and anabolism. It is linked to regulation of morphogenesis, chlamydospore formation, sporulation, cell wall organization, and growth regulation. The product localizes to the nucleus, cytoplasm, cytosol, and cell division site. Studies of related genes in other species link the family to loss of pathogenicity and associations with diseases including meningoencephalitis and pulmonary aspergillosis.