PDC1 — Candida albicans

Summary

PDC1 (C4_06570C_A) on Candida albicans chromosome 4 encodes a pyruvate decarboxylase with pyruvate decarboxylase activity (EC 4.1.1.1), binding thiamine pyrophosphate and magnesium. This enzyme is associated with glycolytic process, ethanol fermentation and anabolism, aerobic respiration, gluconeogenesis, and reactive oxygen species metabolic process. The gene is linked to cell cycle phases (G1, M), host invasion, osmotic response, and regeneration. Its product localises to the cytosol, nucleus, plasmalemma, yeast-form and hyphal cell walls, and fungal biofilm matrix. Phenotypic associations include altered fermentative metabolism, decreased hypoosmotic stress resistance, abnormal cell size and budding patterns, increased flocculation, and changes in nutrient uptake, meiotic recombination, and RNA modification. Studies of related genes in other species connect the family to oxidative stress response.