ABC2 — Candida albicans

Summary

CaABC2 (C4_06910W_A) encodes an ABC transporter with ATP-coupled transmembrane transporter activity, ATP hydrolase activity, and ATP binding, belonging to the ABCG family and containing ABC2 transmembrane and AAA+ ATPase domains. The gene is associated with fluconazole transport, phospholipid transport, ergosterol metabolism, germ tube formation, quorum sensing, phagocytosis, and response to antibiotics and ethanol. It is linked to vacuolar membrane, ER membrane, and plasmalemma localization. Associations include oxidative stress response, decreased endocytosis, abnormal vacuolar morphology and distribution, increased pexophagy, altered cell cycle progression, decreased fermentative metabolism, and increased entry into G0 stationary phase.