GPR1 — Candida albicans

Summary

C5_01250W_A (GPR1) on chromosome 5 of Candida albicans encodes a G protein-coupled glucose receptor, possessing G protein-coupled glucose receptor activity and GPCR activity, and containing EF-hand calcium-binding and glucose receptor domains. The protein localizes to the plasma membrane and cytoplasmic vesicles. GPR1 is associated with the glucose-sensing PKA pathway, the adenylate cyclase-activating GPCR signaling pathway, cellular response to glucose stimulus, and chemoperception. It is linked to filamentous growth regulation, including upregulation in response to chemical stimulus and downregulation in response to heat, as well as to aerobic respiration, mycose metabolism, cell morphogenesis, sexual reproduction, and response to heat. The gene is also linked to innate immunity, immune response, and immune evasion. Studies of related genes in other species connect the family to glucose sensing and signaling.