MYO1 — Candida albicans

Summary

C5_01650C_A (MYO1) in Candida albicans encodes a protein with a myosin head motor domain, kinesin motor domain superfamily features, and P-loop NTPase domain. The gene product exhibits calcium-dependent ATPase activity, microfilament motor activity, calmodulin binding, F-actin binding, small GTPase binding, and ATP binding. MYO1 is associated with cell tip growth, vesicle transport along actin filaments, actin filament bundle retrograde transport, actomyosin contractile ring assembly, cytokinesis, organelle inheritance including peroxisome and ER inheritance, nuclear migration during mitotic telophase, Golgi division, receptor-mediated endocytosis, and intracellular mRNA localization. The protein localizes to the myosin V complex, cortical cytoskeleton, actin filament bundles, transport vesicles, and the LINC complex. Phenotypic associations include absent or decreased septum formation, delayed cytokinesis, abnormal bipolar budding, defective nuclear fusion during mating, absent cell fusion, delayed pexophagy, and arrested cell cycle progression in anaphase.