TAC1 — Candida albicans

Summary

C5_01840C_A, symbol TAC1, on Candida albicans chromosome 5, encodes a Zn2Cys6 DNA-binding transcription factor with DNA-binding transcription activator activity and transcription coactivator activity. The protein belongs to the AtrR-like family and localises to the nucleus as part of a transcription regulator complex. TAC1 is associated with the regulation of cellular response to drugs, including sensitization and demethylation, and is linked to quorum sensing, biofilm formation, and filamentous growth in response to biotic stimuli. It has been connected to hyphal growth, phagocytosis, and the cellular response to oxidative stress. The gene is also associated with sterol and glucan metabolism, TOR signaling, and mitotic recombination, as well as the cellular response to steroid hormone stimulus and response to farnesol.