HSP9 — Candida albicans

Summary

C5_02080C_A (HSP9, also known as HSP12) on chromosome 5 of Candida albicans encodes a member of the HSP9/HSP12 family. The product is associated with lipid binding and localizes to the yeast-form and hyphal cell walls, the plasma membrane, and the cytosol. This gene is associated with regulation of morphogenesis, germ tube formation, quorum sensing, biofilm formation, hyphal growth, mating, cell adhesion, and responses to heat, oxidative stress, and other stresses. Phenotypic associations connect HSP9 to altered thermotolerance, desiccation resistance, biofilm formation, pseudohyphal growth, cell size, viability, and carbon source utilization. The gene is also linked to changes in prion inheritance, pexophagy, mitophagy, autophagy, telomere length, and cell cycle progression.