INT1 — Candida albicans

Summary

C5_02470W_A (INT1) in Candida albicans encodes a protein containing a PH domain and a PH-like domain superfamily, with molecular functions including calmodulin binding, phosphatidylinositol-4,5-bisphosphate binding, and GTP binding. This gene is associated with numerous biological processes such as thigmotropism, germ tube formation, contact guidance, septin ring organization, axial bud site selection, cell-substrate adhesion, and symbiotic interaction with the host. It localizes to the septin ring, bud neck, and cell division site. INT1 is linked to traits including salt tolerance and a wide range of phenotypes such as abnormal cytokinesis, budding, and actin cytoskeleton morphology, increased cold sensitivity, altered metal and toxin resistance, decreased vegetative growth, and cell cycle arrest. Studies of related genes in other species connect the family to similar cellular organization processes.