CREA — Candida albicans

Summary

C5_02940C_A (CREA, also known as MIG1) in Candida albicans encodes a transcription factor of the CreA/MIG1 family that binds double-stranded DNA and RNA polymerase II cis-regulatory regions, with zinc-binding and transcription factor activity. This gene is associated with negative regulation of transcription by glucose, carbon utilization regulation, germ tube formation, quorum sensing, response to host, and innate immunity. It localizes to both cytoplasm and nucleus. Associations include oxidative stress response, abnormal pseudohyphal growth, decreased adhesion, altered chitin deposition, increased sporulation, and decreased fermentative growth. The gene is also linked to disseminated candidiasis in humans and mouse models. Studies of related genes in other species connect the family to sugar content and germination rate.