EFG1 — Candida albicans

Summary

CaEFG1 (C5_04910W_A) on chromosome 5 of Candida albicans encodes a protein containing an EFG1_rRNA-proc domain. The gene is associated with a wide range of biological processes, including farnesol anabolism and response to farnesol, filament development, regulation of morphogenesis, proline metabolism, carbohydrate storage, and response to hypoxia. It is linked to the nucleolus and the preribosome small subunit precursor. Phenotypic associations include increased filamentous growth, altered cell cycle progression, increased stress resistance and thermotolerance, decreased cell size, abnormal budding pattern, and changes in telomere length. The gene is also associated with polysaccharide content, calcium sensitivity, and oxidative stress response. Studies of related genes in other species link the family to ribosome biogenesis.