CNAB — Candida albicans

Summary

C5_05160C_A (CNAB, CNB1) encodes a protein with EF-hand calcium-binding domains and exhibits calcium-dependent protein serine/threonine phosphatase regulator activity, phosphatase binding and activator activity, and calcium ion binding. CNAB is associated with calcineurin-mediated signaling, calcium ion homeostasis, response to calcium ions, fungal-type cell wall organization, biofilm formation, ER stress response, cellular thermotolerance, regulation of cell morphogenesis, conjugation with cellular fusion, and interaction with host. It localizes to the calcineurin complex, cytoplasm, nucleus, and cell division site. The gene is linked to phenotypes including abnormal filamentous growth, cell cycle progression defects, absent hyperosmotic stress resistance, altered shmoo formation, and abnormal bipolar budding pattern. Studies of related genes in other species connect the family to virulence and pathogenicity.