ABR1 — Candida albicans

Summary

C6_00440C_A (ABR1, also known as FET34) in Candida albicans encodes a multicopper oxidase of the Fet3-like family with ferroxidase activity, iron channel activity, and copper binding. The gene is associated with iron transport, reductive iron assimilation, cellular responses to iron and copper, biofilm formation, filamentous growth in response to starvation, prostaglandin and arachidonic acid metabolism, eoxin synthesis, melanin and pigment anabolism, and sterol metabolism. It localises to the plasma membrane, high-affinity iron permease complex, extracellular vesicles, and the fungal biofilm matrix. The gene is linked to oxidative stress response and numerous phenotypes including altered alkaline pH resistance, decreased anaerobic and fermentative growth, abnormal replicative lifespan, and absent sporulation and spore germination. Studies of related genes in other species connect the family to iron and copper sensitivity and reduced virulence.