CDCA — Candida albicans

Summary

C6_00670W_A (CDCA, also known as CDC14) encodes a dual-specificity phosphatase with protein tyrosine/serine/threonine phosphatase activity (EC 3.1.3.48), belonging to the CDC14 family. In Candida albicans, this gene is associated with the regulation of cell septum assembly, cytokinesis, mitotic spindle dynamics, and exit from mitosis. It localizes to the RENT complex, mitotic spindle midzone, actomyosin contractile ring, and spindle pole body. Phenotypic associations include temperature-sensitive growth, cell cycle progression defects (G1 acceleration, G2 deceleration, anaphase delays), absent or decreased septum formation, increased polyploidy, and abnormal mating efficiency. The gene is also linked to arginine metabolism, rDNA packaging, and septin ring assembly. Studies of related genes in other species connect the CDC14 family to mitotic exit control and cytokinesis regulation.