GPX1 — Candida albicans

Summary

CaGPX1 (C6_00850W_A) on chromosome 6 of Candida albicans encodes a phospholipid-hydroperoxide glutathione peroxidase with thioredoxin-dependent peroxiredoxin activity (EC 1.11.1.24), belonging to the thioredoxin-like superfamily and GPX domain families. The gene is associated with cell redox homeostasis, oxidative stress response, and cellular detoxification of hydrogen peroxide, as well as with mitochondrial localization. It is linked to host interaction processes including immune response, inflammatory response, cytokine production, opsonization, phagocytosis, T cell polarization, and wound healing, and to pathogenesis-related traits such as germ tube formation and disseminated candidiasis. Phenotypic associations include increased lifespan and vegetative growth, altered cell cycle progression, abnormal Golgi morphology, decreased fermentative and respiratory metabolism, and increased acid pH resistance.