SUR7 — Candida albicans

Summary

C6_01720C_A (SUR7, CaSUR7) in Candida albicans encodes a member of the SUR7/Rim9-like fungal protein family. The gene is associated with cell wall beta-glucan anabolism, phosphatidylserine anabolism, septin cytoskeleton organization, phosphoinositide-mediated signaling, actin cortex stabilization, and plasma membrane organization. It is linked to eisosome, lipid raft, and extracellular vesicle localization. SUR7 has been associated with filamentous growth of a population of unicellular organisms in response to chemical stimulus and neutral pH, cellular responses to copper, glucose starvation, and neutral pH, as well as cell wall biogenesis. Phenotypic associations include abnormal filamentous growth, decreased cell fusion and endocytosis, increased biofilm formation and flocculation, altered nutrient utilization and transport, decreased ionic stress resistance and acquired thermotolerance, and increased mating response. Studies of related genes in other species link the family to abnormal nuclear morphology and decreased sporulation efficiency.