CAF5 — Candida albicans

Summary

CAF5 (also known as MDR1, FLR1, and MFS1) on Candida albicans chromosome 6 encodes a major facilitator superfamily (MFS) multidrug transporter. The protein is localized to the plasma membrane, endoplasmic reticulum, Golgi complex, and peroxisome membrane, and exhibits fluconazole, xenobiotic, and spermine transmembrane transporter activity. CAF5 is associated with fluconazole transport, response to xenobiotic and antibiotic stimuli, ergosterol metabolism, phospholipid transport, quorum sensing, germ tube formation, and nitrogen utilization. Phenotypic associations include increased filamentous growth and stress resistance, decreased viability, autophagy, endocytosis, and alkaline pH resistance, abnormal cell shape and budding pattern, increased mitotic recombination and mutation frequency, and altered cell cycle progression and redox state. The gene is also linked to oxidative stress response and candidiasis. Studies of related genes in other species connect the family to decreased vegetative growth.