ABCA — Candida albicans

Summary

C6_03840C_A (ABCA, also known as SNQ2) in Candida albicans encodes an ABCG-type pleiotropic drug resistance transporter, a member of the ATP-binding cassette superfamily with NTPase activity. The gene product is associated with estradiol, corticosterone, azole, fluconazole, and xenobiotic transmembrane transporter activities, as well as phospholipid floppase and flippase activities. It is linked to responses to progesterone, antibiotics, and xenobiotic stimuli, azole and fluconazole transport, phospholipid translocation, sterol homeostasis, mRNA transcription, wound healing, inflammatory response, nitrogen catabolite repression, and GPI anchor anabolism. The protein localizes to the plasma membrane, membrane, and extracellular vesicles. Phenotypic associations include abnormal small molecule transport, increased fermentative growth, decreased cell death, delayed mitophagy, and cell cycle progression, and replicative and chronological lifespan.