FLO8 — Candida albicans

Summary

C6_04350C_A (FLO8, also known as CaIXR1, CaMED15, IXR1, MED15) in Candida albicans chromosome 6 encodes a DNA-binding transcription activator with a LisH domain. The gene is associated with numerous biological processes including filamentous growth, germ tube formation, flocculation, cell budding, mating projection assembly, phenotypic switching, response to carbon dioxide, sterol homeostasis, sumoylation, sulfur metabolism, and IL-10 production. It localizes to the nucleus and is linked to candidiasis and disseminated candidiasis. Phenotypic associations include altered cell cycle progression through G1, S, G2, and M phases, increased resistance to gamma rays, X rays, UV, and acid pH, abnormal axial budding and silencing, decreased pseudohyphal growth and mating response, increased nutrient utilization, and abnormal subcellular morphology. Studies of related genes in other species link the family to cellulose content, acid sensitivity, and oxidative stress response.