MAP1 — Candida albicans

Summary

C7_00890C_A (MAP1, also known as MCM1) on Candida albicans chromosome 7 encodes a MADS-box transcription factor of the SRF-like family, with DNA-binding, bending, and RNA polymerase II-specific transcription activator activity. The gene is associated with regulation of pseudohyphal and hyphal growth, filamentous growth, phenotypic switching, mating, morphogenesis, cell adhesion, the MAPK cascade, signaling, the immune response, cellular stress responses, DNA damage response, DNA replication, homologous recombination, ribosome biogenesis, and chromatin localization. Phenotypic associations include abnormal cell cycle progression (G1/S arrest, G2 delay, S phase arrest), decreased budding rate, abnormal mating response and pheromone sensitivity, increased shmoo formation, premature chromosome segregation, absent hyperosmotic stress resistance, decreased nuclear fusion during mating, increased nutrient uptake, decreased nitrogen utilization, sterility, abnormal endocytosis, and decreased necrotic cell death.