OGM1 — Candida albicans

Summary

C7_02890C_A (OGM1, also known as PMT1) in Candida albicans encodes a protein O-mannosyltransferase (EC 2.4.1.109) with mannosyltransferase and transglycosidase activity, belonging to the PMT_4TMC family and containing MIR motifs. This gene is associated with protein O-linked glycosylation and mannosylation, fungal-type cell wall organization, hyphal growth, filamentous growth in response to neutral pH and starvation, biofilm formation, cell-substrate adhesion, calcium signaling, immune response, cytokine production, interaction with host, and regulation of ER unfolded protein response. It is linked to candidiasis and has been studied in Mus musculus. The gene product localizes to the ER membrane, nuclear membrane, endomembrane system, and plasma membrane. Associations with mannose content, oxidative stress response, and numerous cellular processes including delayed growth, cytokinesis, and endocytosis have been observed.