CP1 — Candida albicans

Summary

C7_03360W_A (CP1, also known as CPY1) encodes a serine carboxypeptidase (EC 3.4.16.5) belonging to the peptidase S10 family, characterized by a propeptide_carboxypepY domain and active-site serine and histidine motifs. The enzyme is associated with proteolysis, zymogen activation, phytochelatin anabolism, digestion, and cellular response to nitrogen starvation. It localizes to the fungal-type vacuole lumen and is also found extracellularly. Phenotypic associations link CP1 to numerous cellular processes, including abnormal autophagy, decreased ribophagy and mitophagy, altered cell death, increased aneuploidy, abnormal nuclear fusion during mating, delayed endocytosis, and increased acquired thermotolerance. The gene is also associated with protein secretion, prion inheritance, replicative lifespan, and Golgi morphology. Studies of related genes in other species link the family to vacuolar carboxypeptidase function.