CAM1 — Candida albicans

Summary

CAM1 (C7_04110W_A) on Candida albicans chromosome 7 encodes a protein serine/threonine kinase with ATP-binding and lipid-binding activities, containing EF-hand calcium-binding and protein kinase domains. The gene is associated with protein phosphorylation, intracellular signal transduction, TORC1 signaling, and regulation of clathrin-mediated endocytosis. It is linked to vacuolar protein processing, glycogenolysis, actin cortical patch assembly, and filamentous growth including germ tube formation, biofilm formation, and flocculation. The encoded product localizes to the trans-Golgi network membrane, vacuole, Golgi complex, endoplasmic reticulum, cytoplasm, and actin patches. Phenotypic associations link CAM1 to cell cycle progression, particularly G1 phase arrest and increased critical cell size at start, as well as altered filamentous growth, decreased cell size, increased desiccation resistance, decreased telomere length, and increased cold sensitivity. Studies of related genes in other species connect the family to ribosome biogenesis and rRNA processing.