COX1 — Candida albicans

Summary

CM_00210W (COX1) on the Candida albicans mitochondrial chromosome encodes a protein with cytochrome c oxidase subunit 1 domains, a core component of respiratory chain complex IV. This enzyme (EC 7.1.1.9) possesses cytochrome-c oxidase activity, heme binding, and metal binding, and localises to the mitochondrial inner membrane. COX1 is associated with aerobic respiration, oxidative phosphorylation, electron transport coupled proton transport, and mitochondrial electron transport from cytochrome c to oxygen. It has also been linked to mitochondrial transcription, RNA breakdown, secretion, and the anabolism of prostaglandins and fatty acids. Phenotypic associations include altered respiratory metabolism, nitrogen source utilisation, mitochondrial genome maintenance, cell cycle progression, budding, cytokinesis, spore wall formation, desiccation resistance, and increased mutation frequency. Studies of related genes in other species link the family to oxidative stress response.