COX1 — Candida albicans

Summary

CM_00230W (COX1) on the Candida albicans mitochondrial chromosome encodes a protein with cytochrome-c oxidase activity, heme binding, and endonuclease/hydrolase activity, placing it in the cytochrome c oxidase subunit 1 family. It is associated with aerobic respiration, electron transport coupled proton transport, mitochondrial electron transport from cytochrome c to oxygen, and oxidative phosphorylation. The gene is also linked to intron homing, mitochondrial transcription, RNA breakdown, secretion, and the biosynthesis of prostaglandins and fatty acids. Its product localizes to the mitochondrial inner membrane as part of respiratory chain complex IV. Studies of related genes in other species further connect the family to cytochrome-c oxidase (EC 7.1.1.9) and hydrolase (EC 3.1.-.-) activities.