MDH1 — Candida albicans

Summary

CR_00540C_A (MDH1) in Candida albicans encodes a malate dehydrogenase with NAD-L-malate dehydrogenase and L-lactate dehydrogenase (NAD+) activities (EC 1.1.1.37), placing it in the lactate/malate dehydrogenase family. The gene is associated with the TCA cycle, gluconeogenesis, the malate-aspartate shuttle, and metabolism of malate, citrate, glutamate, lactate, pyruvate, and ergosterol. It is linked to mitochondrial and cytoplasmic localisation, as well as nuclear presence. Phenotypic associations include abnormal respiratory and fermentative metabolism, decreased mitochondrial transport and nutrient uptake, increased ionic stress resistance and survival in stationary phase, altered mating response, and absent budding, mitophagy, and silencing. Related genes in other species connect the family to malate dehydrogenase activity (EC 1.1.1.27).