ABC2 — Candida albicans

Summary

CR_02150W_A (ABC2/MDL1) on Candida albicans chromosome 8 encodes an ABC-type oligopeptide transporter with ATP-coupled transmembrane transporter activity, ATP hydrolase activity, and ATP binding, belonging to the type 1 exporter family with ABC transporter and AAA+ ATPase domains. The gene is associated with mitochondrial inner membrane and plasma membrane localization, and has been connected to diverse biological processes including fluconazole transport, ergosterol metabolism, phospholipid transport, germ tube formation, quorum sensing, phagocytosis, response to ethanol, nitrogen utilization, mRNA transcription, and sulfur amino acid metabolism. Associations also include oxidative stress response, decreased hypoosmotic stress resistance, abnormal vacuolar morphology and distribution, increased pexophagy, decreased endocytosis rate, abnormal cell cycle progression, decreased fermentative metabolism, and increased entry into G0 stationary phase.