CLR6 — Candida albicans

Summary

CR_02760C_A (CLR6, also known as RPD3) on Candida albicans chromosome 8 encodes a histone deacetylase with NAD-independent activity, specifically deacetylating histones H3 and H4 at multiple lysine residues. This enzyme is a core component of several chromatin-modifying complexes including HDA1, Rpd3S, SHREC, and SET3C, and localizes to euchromatin, heterochromatin islands, and subtelomeric regions. CLR6 is associated with epigenetic regulation of gene expression, chromatin silencing, and heterochromatin assembly. It is linked to filamentous growth in response to pH, starvation, and biotic stimuli, as well as phenotypic switching and autophagy regulation. Phenotypic associations include abnormal cell cycle progression, mating type switching, biofilm formation, flocculation, and sporulation rate. Related genes in other species are associated with acid sensitivity.