PIR1 — Candida albicans

Summary

CR_04990C_A (symbol PIR1) on Candida albicans chromosome 8 encodes a PIR family cell-wall mannoprotein, characterized by a PIR1-like C domain and annotated as a structural constituent of the cell wall with 1,3-beta-D-glucan binding activity. The gene is associated with fungal-type cell wall biogenesis, organization, and assembly, and its product localizes to the yeast-form cell wall, fungal-type cell wall, biofilm matrix, and extracellular space. PIR1 is associated with hyphal growth, filamentous growth, biofilm formation, chlamydospore formation, mating, immune evasion, phagocytosis, oxidative phosphorylation, demethylation, vitamin and ergosterol anabolism, and cellular response to thermal stimulus. It is also linked to relative growth rate. Related genes in other species are linked to increased virulence and disseminated candidiasis.